Russia launched an intercontinental ballistic missile from its southern Astrakhan region during a morning attack on Ukraine on Thursday, Kyiv's air force said, the first time Russia has used such a powerful, long-range missile during the war.
The strike comes after Ukraine used U.S. and British missiles to strike targets inside Russia this week, something Moscow had warned for months would be seen as a major escalation.
The Russian attack targeted enterprises and critical infrastructure in the central-eastern city of Dnipro, the air force said, at a time of escalating moves in the 33-month-old war launched by Russia in Ukraine.
It was unclear from the statement what the intercontinental ballistic missile targeted and whether it caused any damage.
The missiles have a range of thousands of kilometers and can be used for delivering nuclear warheads, though they can also have conventional warheads.
Ukrainian air defenses shot down six Kh-101 cruise missiles during the attack.