Rita will perform songs in Persian from her latest album, "My Joys," as well as some of her greatest hits.
The performance is expected to be viewed by the UN secretary-general, the General Assembly president, ambassadors and diplomats, leaders of the Jewish and Iranian communities and American artists.
Israeli Ambassador to the UN Ron Prosor will address the audience before Rita takes the stage.
"The world will get to see the real Iranian bomb – Rita," he jokes.
According to the ambassador, "The sounds usually heard at the General Assembly hall are of condemnation and criticism against us. During Rita's performance, different sounds will echo – sounds of hope, peace and multiculturalism. This is the real sound of Israel.
"While we connect people through music, the only instruments the Iranian leadership plays on are the drums of war."
Rita's performance at the UN was devised when Prosor attended the singer's concert in New York several months ago.
"Only a person like him can find the courage and leadership, in a world losing its sanity, to create such a unique opportunity for an international musical performance that could benefit our world, even if just a little bit," says Rita, who is very excited ahead of the performance.
"I am totally aware of the rareness of this event, especially with the UN secretary-general, General Assembly president and ambassador speaking there."
The upcoming UN performance stands as further proof of the fact that Rita's Farsi album has gained popularity widely beyond expectations.
"The proximity of events has led to the release of the Persian album during our most tense period with the Iranian regime – and I stress, not with the Iranian people," she says.
Adi Gold contributed to this report