Over 160 genetic risk factors have been identified for restless legs syndrome (RLS), a condition characterized by an irresistible urge to move the legs, often worsening at night and disrupting sleep. RLS affects up to 10% of the population, with a higher prevalence in women.
Genetic studies have revealed a strong hereditary component in RLS, with the first genome-wide association study 20 years ago identifying 3 genetic regions associated with the condition.
A new study increased the number to 164. The dataset for the study included the INTERVAL study of England's blood donors in collaboration with NHS Blood and Transplant. The ability to predict RLS risk has been achieved for the first time, offering opportunities for prevention and treatment.
RLS is likely influenced by a combination of genetic, environmental, and hormonal factors, and may be a risk factor for developing type 2 diabetes. Genetic differences involving glutamate receptors 1 and 4 have been identified, potentially offering targets for existing drugs or new drug development.
This article was written in collaboration with Generative AI news company Alchemiq
Sources: Nature, The Naked Scientists, cam.ac.uk, Live Science